MIF、CD68和CD57在卵巢癌组织中的表达及其意义

Expressions of MIF,CD68 and CD57 in ovarian cancer tissues and their significances

目的:探讨巨噬细胞移动抑制因子、巨噬细胞及自然杀伤细胞标记物MIF、CD68及CD57在卵巢癌组织中的表达及意义。方法:采用免疫组织化学法检测56例卵巢癌和5例正常卵巢组织中MIF、CD68及CD57蛋白的表达情况。结果:正常卵巢组织中,MIF有少量表达,CD68、CD57均无表达;卵巢癌组织中MIF、CD68、CD57均有阳性表达,随着肿瘤恶性度的升高CD57、CD68、MIF阳性表达量有增多趋势,与正常卵巢组织比较差异有显著性(P<0.05)。各级别卵巢癌组织中CD57表达量明显低于CD68表达量(P<0.05)。结论:卵巢癌组织中MIF蛋白表达上调导致巨噬细胞和自然杀伤细胞增多,可能是肿瘤进一步恶化的原因之一。

Objective To study the expressions of MIF,CD68 and CD57 which are the markers of macrophages,macrophage migration inhibition factors and natural killer cells in ovarian cancer tissues and their significances. Methods Immunohistochemistry staining was used to detect the expressions of MIF,CD68 and CD57 in 56 ovarian cancer tissues and 5 normal ovary tissues. Results MIF,CD68 and CD57 had positive expressions in ovarian cancer tissues at different degrees,but the expressions of MIF,CD68 and CD57 were week or negative in normal ovary tissues.Furthermore,the positive expression levels of MIF,CD68 and CD57 in ovarian cancer tissues were increased with the grade of ovarian cancer.The expression of CD57 was lower than the expression of CD68 in ovarian cancer（P〈0.05）.Conclusion The up-regulated expression of MIF can make the increase of macrophages and natural killer cells,it is one of the reasons of tumor development.