儿童肾病综合征纤维蛋白原含量、血小板参数、免疫球蛋白变化分析

Clinical significance of fibrinogen,thrombocyte parameter and immunoglobulin in nephrotic syndrome

目的探讨各型NS患儿血浆纤维蛋白原含量、血小板参数、免疫球蛋白水平的变化及临床意义。方法回顾性分析99例NS患儿血小板计数(BPC)、血小板分布宽度(PDW)、大血小板比率(P-LCR)、纤维蛋白原含量(FIB)、免疫球蛋白IgA,IgG,IgM并进行统计学分析。结果肾炎型和单纯型NS患儿相比,血小板计数(BPC)、纤维蛋白原含量(FIB)、大血小板比率(P-LCR)明显升高,血小板分布宽度(PDW)及IgG明显降低,两组间差异具有显著性(P<0.05),IgA、IgM,两组间差异无显著性(P>0.05)。结论FIB,BPC,P-LCR,PDW,IgG的监测对NS患儿体内高凝状态的判断,临床分型用药的指导及病情的推测具有积极意义。

Aim To explore clinical significance of fibrinogen, thrombocyte parameter and immunoglobulin in nephrotic syndrome. Methods 99 patients with NS were studied by using retrospective analysis. Blood platelets count （ BPC ）, platelet distribution width （ PDW ）, proportion of big platelet （ P-LCR ）, content of fibrinogen （ FIB ）, immunoglobulinG （ IgG）, immunoglobufinA （ IgA ）, immunoglobulinM （IgM） were compared in each group. Results The levels of BPC, FIB and P-LCR of nephritic type NS was significantly higher than those in simple type NS and the levels of PDW and IgG of nephritic type NS was significantly lower than those in simple type NS（ P 〈 0 . 05 ） ,while the levels of PDW and IgM were no singuificantly different in each group. Conclusion Detecting the levels of FIB, BPC, P-LCR, PDW and IgG is useful to estimate the state of blood coagulation, patients＇ condition and prognosis, and guide clinical typ- ing and clinical medication in NS patients.