磁性纳米粒子介导肿瘤核磁共振成像及热疗

Research status of magnetic nanoparticles mediated tumor MR imaging and hyperthermia

磁性纳米粒子介导肿瘤治疗作为一种新型肿瘤治疗技术，推动肿瘤热疗向靶向定位和精确控制的方向发展。近年来研究学者们在对磁性纳米粒子的表面修饰、与放化疗的联合应用以及临床应用进行深入研究的同时，发现超顺磁性铁氧体纳米粒子经表面修饰获得水溶性后，可做核磁共振（MR）造影剂．这种集诊断与治疗于一体的磁性纳米粒子，将进一步推动磁性纳米粒子介导肿瘤治疗向更安全、有效的方向发展。

Magnetic nanoparticles mediated hyperthermia, as a new kind of tumor therapy, promotes tumor hyperthermia to targered localization and precise control. In recent years, researchers stvdy deeply on surface modification of magnetic nanoparticles, combination with radiotherapy and chemotherapy, as well as clinical application, at the same time, researchers find that superparamagnetic ferrite nanoparticles after obtai- ning water-soluble by surface modification, can be as the MR imaging agent. Magnetic nanoparticles both for tumor diagnosis and treatment, will further promote tumor therapy to a more safe and effective direction.