直肠癌新辅助治疗后病理降期相关研究进展

Histopathological regression after preoperative chemoradiotherapy in locally advanced rectal carcinoma

术前同步放化疗已成为局部晚期直肠癌的标准治疗模式。新辅助治疗后病理降期与直肠癌预后关系密切，找到能预测直肠癌新辅助治疗病理降期标记，有着重要的临床意义。不同放化疗方案、靶向药物在新辅助治疗中的应用、新辅助治疗后至手术间隔时间与病理降期相关。

Neoadjuvant chemoradiotherapy （CRT） has become a standard treatment of locally advanced rectal carcinomas. There is a close correlation between histopathological regression after preoperative CRT and prognosis. To identify the markers for histopathological regression is significant for clinical treatment. Different strategies of chemoradiotherapy, application of targeted drugs in neoadjuvant chemothercepy and internal from neoodjuvant to operation are correlated with histopathological regression.