抗生素相关性肠炎合并中毒性巨结肠6例

Antibiotic-related Enteritis Leading to Toxic Megacolon： Report of 6 Cases

为探讨抗生素相关性肠炎合并中毒性巨结肠的诊治，回顾性分析6例抗生素相关性肠炎合并中毒性巨结肠的临床资料。3例治愈患者中有2例经大剂量生长抑素治疗，3例治疗无效行手术治疗，其中1例行坏死结肠切除，2例行结肠造口，均死亡。结果表明，大剂量生长抑素治疗抗生素相关性肠炎合并中毒性巨结肠有效，手术治疗死亡率较高。

The aim of this study was to explore the therapy for toxic megacolon leaded by antibiotic-related enteritis. Authors analysed the clinical data on 6 patients with this disease retrospectively. Outcome of analysed data included t among 3 cured cases 2 were subjected to large-dosage of somatostatin;rest 3 cases secondaryly to surgical treatment due to non-response of somatostatin therapy,one case of the 3 cases to resection of necrosis colon, 2 cases of the 3 cases to colostomy,but they all died. These results show that large-dosage of somatostatin is an effective therapy for toxic megacolon induced by antibiotic-related enteritis,while surgical treatment has higher death rate.