摘要
利用CSPM5000型原子力显微镜观察了吸附在云母基底上的红细胞表面形貌,对比分析了云母表面和红细胞表面微摩擦力回路曲线及摩擦力-载荷关系曲线,通过观察红细胞表面形貌及对其表面进行摩擦力分析发现:由于红细胞表面柔软粗糙,且其表面吸附一定的血浆和水,导致测得微观摩擦力较大;红细胞表面的摩擦力随载荷的增大而增大;坚硬的探针与柔软的红细胞表面接触并施加一定的载荷时,载荷增大首先使红细胞发生变形,当载荷增大到红细胞膜的变形极限时会导致红细胞膜破损,此时所测得的摩擦力为探针切割红细胞膜的力。
The surface morphology of red blood cell adsorbed on the surface of mica was observed by using the atomic force microscope （AFM） of CSPM5000. The micro-friction between erythrocyte and probe, and the relation between load and friction force were studied. The result shows that erythrocyte morphology has definite influence on the micro-friction, and moisture, plasma and surface charge adsorbed on the erythrocyte surface also have some effect on the friction force of the blood cell. Friction force increases with the increase of load. With the increase of load, the distance between probe and erytbrocyte surface decreases, which first makes the micro-friction increase, then results in the deformation of erytbrocyte membrane, age may be at last results in the erythrocyte membrane damage. The friction that results in the erythrocyte membrane damthe force of probe cutting the erythrocyte membrane
出处
《润滑与密封》
CAS
CSCD
北大核心
2009年第12期10-14,共5页
Lubrication Engineering
基金
国家自然科学基金项目(50775223)
关键词
AFM
红细胞
表面形貌
微摩擦力
细胞膜损伤
AFM
red blood cell
surface morphology
micro-friction
membrane damage
