2型糖尿病正常糖耐量一级亲属游离脂肪酸变化与胰岛素抵抗的关系

Relationship between FFA and insulin resistance in type 2 diabetes mellitus and their normoglycemic first-degree relatives

目的观察2型糖尿病患者及其一级亲属游离脂肪酸的变化与胰岛素抵抗的关系。方法随机选取38例2型糖尿病患者作为糖尿病组;56例上述患者正常糖耐量一级亲属作为观察组;35例健康志愿者作为对照组。比较他们游离脂肪酸的变化与胰岛素抵抗的关系。结果观察组与对照组相比,血清FPG、PPG、HbA1C、FFA、TG、Homa-IR显著升高(均为P<0.05);Homa-IS及ISI显著降低(P<0.05);Pearson相关分析显示,观察组FFA与FPG、TG呈显著正相关(r=0.289,P=0.031;r=0.273,P=0.042),与Homa-IR、TCH、ApoB100、BMI、WHR、MDA呈正相关(r=0.091,r=0.120,r=0.060,r=0.163,r=0.056,r=0.118,均为P>0.05),与Homa-IS、ISI呈负相关(r=-0.125,r=-0.039,均为P>0.05)。结论2型糖尿病患者一级亲属血糖正常时已存在脂代谢紊乱、胰岛素抵抗及β细胞功能受损,且FFA与胰岛素抵抗存在相关性。

Objective： To study the relationship between FFA and insulin resistance in type 2 diabetes mellitus and their normoglycemic first-degree relatives.Methods： 38 type 2 diabetic patients served as diabetes group and 56 normoglycemic first-degree relatives as observation group and 35 healthy controls without diabetic family history as control group.Results： FPG,PPG,HbA1c,FFA,TG and Homa-IR were higher and Homa-IS and ISI were significantly lower in the normoglycemic first-degree relatives than those in the controls（P〈0.05）.Pearson correlate analysis showed that FFA had significantly positive correlation with FPG and TG in observation group（r=0.289,P=0.031;r=0.273,P=0.042）.FFA had positive correlation with Homa-IR,TCH,ApoB100,BMI,WHR and MDA（r=0.091,r=0.120,r=0.060,r=0.163,r=0.056,r=0.118,each was P〉0.05） and had negative correlation with Homa-IS and ISI（r=-0.125,r =-0.039,each was P〉0.05）in observation group.Conclusion： The first-degree relatives of type 2 diabetes had had dyslipidoses,insulin resistance and the deficiencies of islet beta cell when they had normal blood glucose.There is a relationship between FFA and insulin resistance.