立体定向放射治疗原发性肝癌的疗效分析

The analysis of therapeutic effect of primary liver cancer treated by stereotactic radiotherapy

目的分析立体定向放射治疗原发性肝癌的疗效。方法采用γ射线立体定向放射治疗266例原发性肝癌患者,PTV周边照射总剂量为3200～4600cGy,分割处方剂量为300～600cGy,1次/日,6次/周,7～10次完成治疗。结果总有效率(CR+PR)为79%,无变化(SD)18%,进展(PD)3%。1年、2年、3年生存率分别为71.2%、40.3%、22.8%。本组治疗无放射诱发的肝病(RILD)发生,主要反应为上腹部不适,食欲下降。结论立体定向放射治疗原发性肝癌是一种疗效确切、副作用较小的临床治疗方法。

Objective To analyze the therapeutic effect of primary liver cancer treated by stereotactic radiotherapy. Methods 266 patients with primary liver cancer were treated with γ ray stereotatic radiotherapy（SRT）. The dose of 3200～4600cGy（300～500eGy/F,6F/w） were delivered to PTVs over 7 to 10 fracions,6 consecutive fractions per week. Results All patients were examined with image of CT or MRI. The total effective rate （CR＋PR）,steady diseae （SD）,progressive disease （PD） was 79%,18% and 3%. The 1,2,3-year survival rates of pateents were 71.2%,40.3%,22.8%,respectively. No RILD and serious side effect occurred,and the gastrointestinal complications were uncomfortable in upper abdomen and poor appetite. Conclusions Stereotactic radiotherapy has good effect and little side effect in the treatment of primary liver cancer.