轻度认知功能障碍与血浆同型半胱氨酸水平的相关性研究

The relationship between mild cognitive impairment and plasma homocysteine

目的探讨轻度认知功能障碍（MCI）与血浆同型半胱氨酸、维生素B12、叶酸水平的关系。方法68例MCI患者测定血浆同型半胱氨酸、维生素B12、叶酸水平及简易精神量表评分等，并与70例健康老人作对照。结果MCI患者血浆HCY明显高于对照组，而维生素B12、叶酸水平明显低于对照组（均P〈O．05）；在轻度认知功能障碍组，当患者血浆HcY〉15umol／1时，其轻度认知功能障碍的优势比OR值为4．3，95％CI为1．89～7．43．MCI患者HCY水平与维生素B12、叶酸水平及评分均称负相关关系。结论血浆HCY升高是MCI的重要因素，体内叶酸、维生素B12缺乏是导致血浆HCY升高的原因。

Objective To investigate the relationship between mild cognitive impairment（MCI）and plasma homocysteine level. Methods Rate of mini mental examination（MMSE） and levels of plasma homocyteine and folate and vitamin B12 were determined in 68 mild cognitive impairment patients, which were compared with 70 healthy elderly. Results The mean plasma level HCY was higher in MCI patients than that in contrast group, and the very reverse of plasma level of folate and vitamin B12 （P〈0.01）. In MCI group, when HCY〉15μmol/L, the odd ratio （OR） was 4.3（95% CI 1.89~7.43）. Plasma level of HCY was negatively correlative with that of folate and vitamin B12 and rate of MMSE in two groups. Conclusion The high level of plasma HCY is an important risk factor to MCI patients. The lack of nutrition elements of vitamin B12 can result in the rising of plasma HCY.