摘要
目的观察替米沙坦在降压的同时对心脏和肾脏的保护作用。方法选择在我院门诊的1、2级原发性高血压患者80例,停用其他降压药2周后,口服替米沙坦80mg,平均观察2年,比较治疗前后超声心动图指标、ST段改变、血β2-微球蛋白和尿24h、β2-微球蛋白的改变。结果治疗后超声心动图指标、ST段改变、血β2-微球蛋白和尿24h、β2-微球蛋白,与治疗前比较均有不同程度的改善,差异均有统计学意义(P<0.01或P<0.05)。结论替米沙坦在治疗高血压的同时对心脏和肾脏有很好的保护作用,但应长期坚持治疗。
Objective To investigated the protection effect on heart and kidney of telmisartan,while brough high blood pressure down.Methods Choice in our hospital out-patients with essential hypertension 1,2-grade 80 cases,out 2 weeks after the other antihypertensive drugs,oral telmisartan 80mg,the average observed for 2 years to compare echocardiographic parameters,ST segment changes,blood and urine 24h β2-microglobulin changes before and after treatment.Results After treatment,echocardiographic parameters ST
segment changes, blood and urine 24h β2 -microglobulin compared with those before treatment have improved to varying degrees, the differences were statistically significant （P 〈 0.01或 P〈0.05 ）. Conclusion Telmisartan in the treatment of hyprtension,while heart and kidney had a good protective effect, but it should be a long-term treatment adherence.
出处
《临床合理用药杂志》
2009年第21期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
