静脉注射6%羟乙基淀粉130/0.4和呋塞米治疗急性胰腺炎的初步研究

Preliminary study on the treatment of acute pancreatitis by 6% hydroxyethylstarch 130/0.4 (Voluven) and furosemide

目的观察静脉输注6%羟乙基淀粉130/0.4(万汶)和静脉推注呋塞米(速尿)对急性胰腺炎转归的影响。方法入院当天即给予患者万汶静脉输注(成人通常为1000～2000ml),同时静脉推注呋塞米,力求作到出入量基本平衡;入院第2天开始逐渐减少万汶用量。结果48例急性胰腺炎患者(Ranson评分≥3分者35%,Balthazar CT评分≥D或E者48%),胰腺局部并发症和全身并发症仅为6%和4%,胰腺手术率为4%,1个月病死率为2%。结论静脉输注万汶和静脉推注呋塞米可改善急性胰腺炎的转归。

Objictive To studied the effects on the outcome of acute pancreatitis cases by intravenously administered 6% hydroxyethyl starch 130/0.4 （voluven） and the intravenous injection of furosemide.Methods Patients were given intravenous infusions of voluven （1 000～2 000ml administered for an adult） on the admission day.At the same time,fuorosemide was administered as intravenous bolus,trying to maintain a fluid balance.The amount of voluven administered gradually decreased from the second day.Results 48 patients （35% of patients with a Ranson＇s score≥3 and 48% with a Balthazar CT ≥ D） were treated with our protocol. Only 6% and 4% patients developed pancreatic and systemic complications respectively, only 4% patients undergone necrosectomy and pseudocyst drainage, and only 2% patients died in one month. Conclusion Our preliminary results suggested that intravenously administered 6% hydroxyethyl starch 130/0.4 solution（voluven） and furosemide might be beneficial for patients with acute pancreatitis.