沙苑子黄酮对D-半乳糖所致亚急性衰老模型小鼠的抗衰老作用研究

Anti-aging Effect of Flavonoids of Astragalus complanatus on D-galactose-induced Subacute Aging in Mice

目的:研究沙苑子黄酮(FAC)对D-半乳糖致亚急性衰老模型小鼠的作用。方法:制备小鼠D-半乳糖亚急性衰老模型,检测FAC对模型小鼠衰老相关酶、免疫器官指数、耐缺氧时间、游泳时间等指标的影响。结果:FAC能明显提高衰老小鼠血中SOD活性,降低MDA含量,明显提高脾指数和胸腺指数,延长衰老模型小鼠缺氧条件下的存活时间和游泳时间。结论:FAC具有抗衰老作用,且能增强小鼠耐缺氧和耐疲劳能力,其作用可能与其增强小鼠非特异性免疫功能有关。

OBJECTIVE： To study the effect of flavonoids of Astragalus complanatus（FAC） on D galactose- induced sub - acute aging in mice. METHODS.. The subacute aging miee model were established with the use of D - galactose, and the effect of FAC on the associated indexes in model mice such as enzymes, immune organ indexes, hypoxia tolerance time, swimming time under hypoxic condition etc were recorded. RESULTS ： FAC treatment significantly up - regulated the activity of SOD, down - regulated MDA content, markedly increased the spleen index and thymus index, prolonged the surviving and swimming time markedly under anoxia condition. CONCLUSION ： FAC has anti - aging effect and it can enhance mice＇ s ability against hypoxia and fatigue, which is probably associated to the enhancement of the nonspecific immunity in mice.