姜黄素固体分散体的制备和溶出度考察

Preparation of curcumin solid dispersion and investigation of its dissolution behavior

目的通过姜黄素固体分散体的制备,提高姜黄素的体外溶出度。方法采用溶剂法和熔融法制备固体分散体,考察不同载体的姜黄素固体分散体的性状及体外溶出度实验,筛选并优化处方和工艺。固体分散体的形成通过X-射线衍射及DSC分析证实。结果姜黄素与聚乙烯吡咯烷酮(polyvinyl pyrrolidone,PVP)-K29/32用溶剂法制备的固体分散体的体外溶出最好,最优处方中姜黄素与PVP-K29/32的质量比为1∶6,最优处方中姜黄素在溶出介质人工胃液中30 min累积溶出质量高达98%。结论制备成姜黄素固体分散体可以显著提高姜黄素的体外溶出度。

Objective To prepare curcumin solid dispersion and improve its dissolution rate in vitro. Methods Solid dispersion was prepared by the melting method and the solvent method. Screen of the optimal formulation of solid dispersion was carried out through comparing appearance and measuring dissolution test in vitro of solid dispersion with diffierent base. The formation of solid dispersion was evaluated by X-ray and DSC test. Results Curcumin solid dispersion was prepared by solvent method using PVP-K29/32 in the ratio of 1：6. Curcumin dissolution percentage from the solid dispersion was about 98 % in HCI solution with pH of 1.2 in 30 minutes. Conclusions The dissolution rate of curcumin from the solid dispersion is obviously enhanced.