摘要
NF-κB信号转导途径与肺部的炎症性病变有密切关系,以此信号通路为作用靶点的抗炎治疗是近年研究的热点。本文综述了肺部各种细胞内NF-κB活化的作用以及应用NF-κB抑制剂治疗肺部疾病的研究进展,为急性肺损伤等肺部炎症的药物治疗研究提供参考依据。
Signal transduction of nuclear factor kappa B is closely related to lung inflammation.Targeting on this signaling pathway is a hot research point for anti-inflammation drugs.In this paper,we reviewed the relationship between lung inflammation and nuclear factor kappa B,as well as the advance of nuclear factor kappa B inhibitor treated on lung disease.It is expected to give reference materials for the study of new anti-inflammation drugs.
出处
《现代生物医学进展》
CAS
2009年第20期3972-3975,3985,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金资助项目(NO.30572344)
北京市自然科学基金资助项目(NO.797225)
北京中医药重点学科项目资助(京中重V20)
科技部科技人员服务企业行动项目(SQ2009GJA2005624)
关键词
NF-ΚB
信号转导
炎症
急性肺损伤
nuclear factor kappa B
signal transduction
inflammation
acute lung injury
