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生物体砷代谢及其相关酶与蛋白的研究概况 被引量：2

Study on Organism Arsenic Metabolism and Its Related Enzymes and Proteins
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摘要 砷在自然界分布广泛,主要以砷化物的形式存在,具有较强毒性。可通过多种途径进入人类的生活环境引起健康危害,砷代谢过程涉及到复杂的酶促或非酶促反应过程,近年来以砷代谢为突破口的砷中毒发病机制探索成为新的研究热点,本文就有关砷在生物体内代谢方面的研究做一综述,以期有助于慢性砷中毒作用机制的研究。 Arsenic is widely distributed and has strong toxic. There are many forms of arsenic in nature. There are many ways for Arsenic to enter the man＇s living environment and cause health hazards. Arsenic metabolism relates to complex progress with or without enzyme catalysis. Recently, pathogenesis of arsenic poisoning, with arsenic metabolism as breakthrough, becomes hot point. This article offers a review on the metabolism of arsenic in biological research, and in order to contribute to the mechanism of chronic arsenic poisoning study.
作者 李莉 幕晓玲
机构地区 石河子大学医学院人体解剖与组织胚胎学教研室
出处 《现代生物医学进展》 CAS 2009年第20期3990-3993,共4页 Progress in Modern Biomedicine
关键词 砷中毒 砷代谢 酶及蛋白 Arsenic poisoning Arsenic metabolism Enzymes and proteins
分类号 R135 [医药卫生—劳动卫生] R595 [医药卫生—内科学]
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参考文献22

  • 1Gratti D, Mitra B, Rosen BP. Escherichia coli soft metal iontranslocating ATPases[J]. J Biol Chem, 2000, 275:34009-34012.
  • 2Rosen BP. Transport and detoxification systems for transition metals, heavy metals and metalloids in eukaryotic and prokaryotic microbes[J]. Comp Biochem Physiol A Mol Integr Physiol, 2002, 133:689-693.
  • 3Aposhian HV. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species[J]. Toxicol Appl Pharmacol, 2004, 198( 3 ): 327-335.
  • 4Hayakawa T. A new metabolic pathway ofarsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19[J]. Arch Toxieol, 2005,79(4):183-191.
  • 5Fujino Y. Chronic arsenic exposure and urinary 8-hydroxy-2'-deoxyguanosine in an arsenic-affected area in Inner Mongolia,China [J]. J. Expo Anal Environ Ep idemiol, 2005, 15(2): 147 - 152.
  • 6Tseng CH. Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan[J]. Toxicol Appl Pharmacol, 2005,206(3):299 -308.
  • 7Yu L, Kalla K, Guthrie E, et al. Genetic variation in genes associated with arsenic Metabolism:glutathione S-transferase omegal-1 and purine nucleoside phosphorlase Polymorphisms in European and indigenous Americans [J]. Environ Health Perspect, 2003,111 (11): 1421-1427.
  • 8Nemeti B, Csanaky I, Gregus Z. Arsenate reduction in human erythrocytes and ratstesting the Role of purine nucleoside phosphorlase[J]. Toxicol Sci, 2003, 74(1):22-31.
  • 9Tanaka-Kagawa T, Jinno H, Hasegawa T, et al. Functional characterization of two variant human GSTOI-ls (Ala140Asp and Thr217- Asn)[J]. Biochern Biophys Res Commum, 2003,301 (2):516-520.
  • 10Marnell LL, Garcia-Vargas GG, Chowdhury UK, et al. Polymorphisms in the human monomethylarsenic Acid (MMAv):reductase/ hGSTO1 gene and change in urinary arsenic profiles [J]. Chem Res Toxicol, 2003, 16(2): 1507-1513.

同被引文献51

  • 1孙殿军.我国"十一五"重点地方病防治成就、存在的问题及建议[A]哈尔滨:中国地方病学杂志,20111-3.
  • 2Ahsan H,Chen Y,Kibriya MG. Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase[J].Cancer Letters,2003,(01):57-65.doi:10.1016/S0304-3835(03)00471-3.
  • 3Vahter M. Mechanisms of arsenic biotransformation[J].Toxicology,2002.211-217.
  • 4Naranmandura H,Suzuki N,Suzuki KT. Trivalent arsenicals are bound to proteins during reductive methylation[J].Chemical Research in Toxicology,2006,(08):1010-1018.doi:10.1021/tx060053f.
  • 5Hayakawa T,Kobayashi Y,Cui X. A new metabolic pathway of arsenite:arsenic-glutathione compl exes are substrates for human arsenic methyltransferase Cyt19[J].Archives of Toxicology,2005,(04):183-191.
  • 6Mukherjee B,Salavaggione OE,Pelleymonter LL. Glutathione Stransferase omega 1 and omega 2pharmacogenomics[J].Drug Metabolism and Disposition,2006,(07):1237-1246.
  • 7Schl(a)wicke Engstr(o)m K,Broberg K,Concha G. Genetic polymorphisms influencing arsenic metabolism:evidence from Argentina[J].Environmental Health Perspectives,2007,(04):599-605.doi:10.1289/ehp.9734.
  • 8Nebert DW,Vasiliou V. Analysis of the glutathione S-transferase (GST) gen efamily[J].Human Genetics,2004,(06):460-464.
  • 9Pool-Zobel B,Veeriah S,B(o)hmer FD. Modulation of xenobiotic metabolising enzymes by anticarcinogens-focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis[J].Mutation Research,2005,(1-2):74-92.
  • 10Schmuck EM,Board PG,Whithread AK. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants:implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases[J].PHARMACOGENETICS AND GENOMICS,2005,(07):493-501.doi:10.1097/01.fpc.0000165725.81559.e3.

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现代生物医学进展
2009年 第20期

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