前列腺特异抗原测定对女性高雄激素症的诊断价值

Increased Level of Prostate-Specific Antigen:A Diagnostic Marker of Hypterandrogenism Women

目的:研究前列腺特异抗原(PSA)是否可作为女性高雄激素症诊断的标志。方法:正常对照组50例,高雄激素症组45例,分别测定血清PSA、睾酮(T)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-S)水平,对两组测定值进行统计学分析。结果:正常对照组血清PSA值为(3.56±0.44)pg/ml,高雄激素症组为(9.72±1.39)pg/ml,两组有显著性差异(P<0.01)。血清PSA值与T、DHEA-S值之间呈弱的正相关关系(分别为r=0.226,P<0.05;r=0.255,P<0.05);与SHBG值之间有弱负相关关系(r=-0.228,P<0.05)。结论:PSA可作为女性雄激素增高的标志物而在临床应用。

Objective： To determine whether the increased level of serum prostate-specific antigen（PSA） could be used as a diagnostic marker of hyperandrogenism in women.Methods： Forty-five female patients with hypterandrogenism and 50 healthy control women were detected for the levels of serum PSA,testosterone（T）,sex hormone binding globulin（SHBG） and dehydroepiandrosterone sulfate（DHEA-S）.The results were statistically analyzed.Results： The level of serum PSA was found to be significantly higher in the hyperandrogenism patients than in the healthy controls（9.72 ± 1.39 pg/ml vs 3.56 ± 0.44 pg/ml,P 〈 0.01）,and it showed a weak positive correlation with T（r = 0.226,P 〈 0.05） and DHEA-S（r = 0.255,P 〈 0.05）,and a weak negative correlation with SHBG（r =-0,228,P 〈 0.05）.Conclusion： The increased level of PSA could be used as a diagnostic marker of hyperandrogenism in females.