脑梗死患者颈动脉弹性与脑动脉狭窄的关系研究

The relationship between cerebral artery stenosis and carotid artery elasticity in the ischemia stroke patients by echo-tracking technique

目的应用血管回声跟踪技术探讨脑梗死患者双侧颈动脉弹性相关参数与脑动脉狭窄程度的相关性。方法收集脑梗死患者92例，行CT脑血管造影检查明确脑动脉狭窄情况，根据脑动脉狭窄程度分为两组：轻度狭窄组和中重度狭窄组。采用血管回声跟踪技术测定双侧颈动脉弹性相关参数：僵硬度（β）、弹性模量（Ep）和顺应性（AC）。结果①缺血性脑卒中组与健康人群β、Ep和AC比较差异有统计学意义（P〈0．05）；②脑动脉轻度狭窄组与中重度狭窄组β和Ep比较差异有统计学意义（P〈0．05），AC有下降趋势。结论脑梗死患者颈动脉弹性明显低于正常人，脑梗死患者颈动脉β越高，脑动脉中重度狭窄的可能性越大。

Objective To study the relationship between the cerebral artery stenosis and the carotid artery elasticity in the ischemia stroke patients by echo-tracking technique. Methods Ninety-two ischemia stroke patients were divided into both the mild cerebral arteries stenosis and moderate severe cerebral arteries stenosis groups. CT angiography was performed to evaluate the stenosis of cerebral artery. The changes of the carotid diameter during cardiac cycles were obtained by echo-tracking technique and the quantitative parameters of pressure-strain elastic modulus （ Ep）, stiffness （β） and arterial compliance （AC） were calculated automatically. Results ① There were significant differences （ P 〈 0.05） between the ischemia stroke patient group and the normal adults group in β, Ep and AC. ②There were significant differences （ P 〈0.05） between the mild cerebral arteries stenosis groups and the moderate-severe cerebral arteries stenosis groups in β and Ep. AC was lower in patients with the mild cerebral arteries stenosis groups than that in the moderate severe cerebral arteries stenosis groups. Conclusions The carotid artery elasticity in ischemia stroke patients were significantly different from normal adults. In the ischemia stroke patients, the stiffer the carotid artery was,the higher the likelihood of moderate-severe cerebral stenosis was.