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丹参酮和丹参酚酸类的同步液相色谱-质谱测定及其在大鼠体内的药物动力学 被引量:1

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摘要 目的:丹参有效成分主要包括脂溶性和水溶性成分,其脂溶性成分主要为丹参酮IIA、隐丹参酮、丹参酮I等,具有抗菌消炎,细胞保护与耐缺氧,抑制血小板聚集,改善冠状动脉供血等活性。其水溶性成分主要为丹参素和原儿茶醛等,具有抗自由基与抗脂质过氧化,降血脂以及扩张冠脉,抑制血小板聚集,抗血栓形成,抗肝纤维化等作用。
出处 《中国药理通讯》 2009年第4期10-10,共1页
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  • 1Park EJ;Ji HY;Kim NJ;Song WY;Kim YH;Kim YC;Sohn DH;Lee HS.Simultaneous determination of tanshinone I, dihydrotanshinone 1, tanshinone IlA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF.Biomed Chromatogr,2008:548-55.
  • 2Li J;Wang G;Li P;Hao H. Simultaneous determination oftanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography- electrospray ionisation-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci,2005:26-30.
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  • 4Li P;Wang GJ;Li J;Hao HP;Zheng CN.ldentification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography- tandem mass spectrometry.J Chromatogr A,2006:366-9.
  • 5Li P;Wang GJ;Li J;Hao HP;Zheng CN.Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.Rapid Commun Mass Spectrom,2006:815 -22.
  • 6Li P;Wang GJ;Li J;Hao HP;Zheng CN.Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/ tandem mass spectrometry. J Mass Spectrom,2006:670-84.
  • 7Li P;Wang GJ;Li J;Zhang Q;Liu X;Khlentzos A;Roberts MS.The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.Curr Drug Metab, 2008:39-45.
  • 8Bi HC;Law FC;Zhong GP;Xu CS;Pan Y;Ding L;Chen X;Zhao LZ;Xu Q;Huang M.Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method. Biomed Chromatogr,2007:473-9.
  • 9Bi HC;Zuo Z;Chen X;Xu CS;Wen YY;Sun HY;Zhao LZ,Pan Y;Deng Y;Liu PQ;Gu LQ;Huang ZY;Zhou SF;Huang M.Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases,Xenobiotica,2008:185-222.
  • 10Song M;Hang TJ;Zhang Z;Chen HY.Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone lIA in rat.Eur J Pharm Sci,2007:247-53.

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