Daxx亚细胞定位研究进展

Progress on the subcellular localization of Daxx

死亡域相关蛋白(death domain-associated protein,Daxx)是一种高度保守的核蛋白,在转录调控、致癌、抵抗病毒感染等方面有重要作用。Daxx可定位于早幼粒细胞白血病蛋白核体、核质、核仁、胞浆和异染色质。Daxx通过修饰或与其他蛋白相互作用后能在亚细胞区室之间发生转位。应激条件下,Daxx与多种分子相互作用并发生转位,进而影响下游信号通路。本文综述了Daxx在不同条件下的亚细胞定位及在各亚细胞区室之间的转位。

As a highly conserved nuclear protein, death domainassociated protein （Daxx） plays an important role in transcriptional control, carcinogenesis, resistance to virus infection, and so on. Daxx can be localized in promyleocytic leukaemia protein oncogenic domains, nucleoplasm, nucleolus, cytoplasm, and heterochromatin. The subcellular localization of Daxx can be changed by modification or interacting with .other proteins. Under cellular stress, Daxx can interact with many kinds of molecules, and thus affect its downstream signaling pathway. The purpose of this review was to discuss Daxx＇s subcellular localization in different conditions and its translocation between subceliatar compartments.