摘要
In this genomic era, the research landscape has been taking a dramatic turn in discovering new biological principles that have been unapproachable from traditional studies on the basis of individual genes and this process is accelerating because of technological breakthroughs, largely fueled by the next generation sequencing. Many years of research have established a dogmatic view on transcription that gene promoters drive transcriptional initiation, which is subject to modulation by distal enhancers .
