药物治疗蛛网膜下腔出血后迟发性脑血管痉挛研究进展

Research progress of pharmacotherapy on delayed cerebral vasospasm after subarachnoid hemorrhage

迟发性脑血管痉挛(delayed cerebral vaso-spasm,DCVS)是蛛网膜下腔出血(subarachnoid hemorrhage,SAH)患者致死致残的重要原因,但其病理生理过程仍不明确。对治疗DCVS有效的药物显得尤为重要,包括离子通道阻断剂或开放剂,内皮素(ET)合成抑制剂及其受体拮抗剂,抗炎、抗氧化制剂,纤维蛋白溶解剂和祖国传统医药等。本文综述近年来对SAH后DCVS的基础和临床药物治疗研究进展,探讨各种药物的使用、疗效以及目前存在的争议。

Delayed cerebral vasospasm （DCVS） is an important incapacitating or lethal cause after subarachnoid hemorrhage （SAH）, but the patho-physiological process was vague. The effective drugs of treating DCVS are particularly important including ion channel blockers or openers, endothelin synthetic inhibitor or receptor antagonist, anti-inflammatory agents, antioxidants, fibrinolytic agents, traditional Chinese herbs, etc.The article reviews the research progTess in the preclinical and clinical pharmacotherapy on DCVS after SAH, and explores the applications and effects and debates about these therapeutic drugs at present.