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重组人骨形态发生蛋白-7对大鼠局灶性脑缺血再灌注损伤的保护作用 被引量：2

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摘要 目的探讨重组人骨形态发生蛋白-7(rhBMP-7)对大鼠局灶脑缺血再灌注损伤的保护作用。方法采用线栓法建立局灶脑缺血再灌注模型,随机分为对照组(C组)、缺血再灌注组(I组)和rhBMP-7处理组(B组),B组于再灌注开始前30min给予rhBMP-7250μg/kg尾静脉注射,C组和I组给予等量生理盐水。于血流再灌注后24h行神经功能缺陷评分后取脑,行脑含水量和梗死体积测定,计算脑梗死体积比,并电镜下观察脑超微结构变化。结果B组大鼠脑局灶性缺血再灌注24h后,神经功能缺陷评分明显下降,脑含水量和梗死体积比明显低于I组(P<0.01)。神经细胞的坏死程度也明显轻于I组。结论rhBMP-7缩小梗死体积,减轻脑水肿,对脑缺血再灌注损伤具有保护作用。
作者 许霁虹 赵彦艳 张铁铮 刘晓江 于冬梅
机构地区 中国医科大学医学遗传学教研室 沈阳军区总医院麻醉科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第22期2924-2926,共3页 Chinese Journal of Gerontology
关键词 骨形态发生蛋白-7 再灌注损伤 脑
分类号 R743.31 [医药卫生—神经病学与精神病学]
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参考文献6

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二级参考文献17

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中国老年学杂志
2009年 第22期

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