铜绿假单胞菌的常见耐药机制

Mechanisms underlying the antibiotic resistance of Pseudomonas aeruginosa

铜绿假单胞菌(PA)是目前临床上常见的致病菌,耐药发生率高。耐药的机制涉及外膜的低通透性、外排泵的过度表达、产生灭活酶、靶位的改变或增加等。PA的耐药往往是多方面的,常导致多耐药,给临床治疗带来严峻挑战。

Pseudomonas aeruginosa, a ubiquitous organism, shows a remarkable resistance to antibiotics because of its low permeability of the outer-membrane, over-expression of efflux pumps, inactivation of antibotics, or mutations in targets. These mechanisms are often present simultaneously, and increase the burden on clinical therapy.