广藿香醇的急性毒性实验

Acute toxicity reaction of Patchouli alcohol

目的:观察广藿香醇的急性毒性反应。方法:广藿香醇以最大浓度和最大给药体积的药液灌胃。连续观察14d,记录小鼠毒副反应情况。结果:观察14d,给药组死亡2只,给药后4h,给药组小鼠均表现出不同程度的站立不稳、左右摇晃,但在24h内都恢复正常,小鼠体重给药组与空白对照组比较差异无统计学意义。结论:广藿香醇的最大耐受量小于12.5g/kg。

Objective：To observe the acute toxicity reaction of Patchouli alcohol in mice.Methods： The maximum administration dosage of Patchouli alcohol were determined by ig administration in mice,and its acute toxic reactions were observed for 14 days. Results： Patchouli alcohol lead 2 mice to death,and the others had toxic reaction at different degrees,including unstable standing and tottering. All symptoms were recoverd in 24 hours.Conclusion ： The maximum administration dosage of Patchouli alcohol is 12.5g mg/kg.