新生儿高胆红素血症尿视黄醇结合蛋白测定及临床意义

ASSAY OF URINARY RETINOL BINDING PROTEIN AND CLINICAL SIGNIFICANCE IN NEONATAL HYPERBILIRUBINEMIA

为探讨高胆红素血症对新生儿肾功能影响，应用双抗体夹心酶免疫测定法测定了27例高胆红素血症患儿尿视黄醇结合蛋白（Retinolbindingprotein，RBP）水平。高胆患儿尿RBP水平明显高于正常组。16例患儿当血总胆小于153．9μmol／L时，复查尿RBP，有75％的病例恢复较好。14例患儿同时测定了血肌酐，其结果均在正常范围内。提示：高胆红素血症可造成新生儿短暂性肾小管功能受损。尿RBP是早期肾功能损伤敏感而可靠的检测指标。

In order to explore the effect of renal function in neonatal hyperbilirubinemia, urinary retinol binding protein (RBP) was determined in 27 cases of neonatal hyperbilirubinemia by enzyme-linked immunosorbent assay. The result revealed that the contert of urinary RBP in neonates with hyperbilirubinemia was much higher than that of the normal control subjects and showed a positive relation with the severity of hyperbilirubinemia. Urinary RBP in 16 cases of the patients was reexamed when total serum bilirubin levels had decreased below 153. 9μmol/L. Urinary RBP returmed to normal in 75% of the patients. In addition, among 14 cases of the patients whose plasma creatinine had been determined and the level of the plasma creatinine was all normal. But the urinary RBP in the 14 cases was all higher than that of normal. The data suggested that hyperbilirubinemia can result in renal tubular functional lesion in the newbron. The lesion is transient. Urinary RBP assay may be a sensitive and reliable index for evaluating of early proximal tubular functional impairment.