t-PA结膜下注射治疗术后眼内纤维蛋白渗出

Postoperative intraocular fibrin exudation treated with subconjunctival injection of t PA

目的：观察ｔ－ＰＡ（组织型纤溶酶原激活剂）结膜下注射对术后眼内纤维蛋白渗出的治疗效果。方法：对２０例（２０只眼）术后眼内纤维蛋白渗出患者用浓度为５０μｇ／ｍｌｔ－ＰＡ结膜下注射。每次注射０．５ｍｌ，一次注射不能使纤维蛋白渗出完全溶解者间隔４８～７２小时重复给药，直至吸收。并与同期１９例（１９只眼）用激素治疗眼内纤维蛋白渗出的患者作对照。结果：ｔ－ＰＡ组眼内纤维蛋白完全溶解时间为注药后１～１４天，平均５．２０±３．４９天。对照组则为１～２１天，平均１０．３２±５．９６天，二者相比，有显著性差异（Ｐ＜０．０１）。治疗中未发现出血、眼内压升高等并发症。随访一个月，未见眼内纤维蛋白渗出复发。

The purpose was to investigate the effect of treating postoperative intraocular fibrin exudation with subconjunctival injection of t PA.20 patients(20 eyes) with postoperative fibrin exudation were treated with subconjunctival injection of t PA.The concentration of t PA was 50μg/ml.The dosage was 0.5ml.The interval of repeating treatment was 48～72 hours if intraocular fibrin cant be degraded entirely in the first treatment.19 cases(19 eyes)treated with dexamethasone were contrasted at the same time.The duration of resolution of the intraocular fibrin in the t PA group was 1～14 days(mean 5.20±3 49 days),and in the control group was 1～21 days(mean 10.32±5.69 days).They showed a significant difference( P <0.01).Hemorrhage tendency,increase in intraocular pressure and other complications were not found during the treatment period.There were no recurrent cases during one month follow up survey.Our results demonstrated that the subconjunctival injection of t PA was a safe and effective method of treating intraocular fibrin exudation.