半乳糖性大鼠白内障晶体内前列腺素生物合成的研究

Study on the biosynthesis of prostaglandins in lens from rat with galactose cataract

对半乳糖性白内障晶体内微粒体生物合成前列腺素能力变化分析发现：用５０％半乳糖喂养２４小时后晶体内ＰＧＦ２α水平降至对照组的３１．１１％；４８小时后为对照组的５８．０４％，第５天时为对照组的５２．１９％，在第九天时为对照组的４８．０２％，第２１天时为对照组的３２．１５％，研究发现半乳糖性白内障晶体内前列腺素合成能力受到明显影响。

To study the biosynthesis of prostaglandins in lens from rat with galactose cataract,changes in the biosynthesis of prostaglandins were analysed It was found that 24 hours after being fed with the 50% galactose,the level of prostaglandin F two alpha (F 2α) in the lens from rat with galactose cataract was only 31 11% of that in the normal group 48 hours,5 days,9 days,and 21 days later,the levels of prostagland F 2α in lens with galactose cataract were respectively 58 04%,52 19%,48 02%,32 15% of these in the normal group These results suggested that biosynthesis of prostaglandins in lens was affected by the level of galactose,and it possibly explained the formation of galactose cataract