肥胖基因调控机制研究进展

Progress in the Study of Obesity Gene etiology

肥胖机制的研究是目前最为活跃并取得迅速进展的领域之一。成功完成了克隆肥胖基因(obese gene,ob gene)、阐明ob基因产物—leptin(瘦素LP)的结构、克隆LP受体的基因并部分阐明LP作用的机制,使肥胖研究跨入分子时代,为人类从根本上控制体重、提高健康水平,展现了诱人的前景。本文就肥胖基因的调控作用方面综述最新进展。

The study of obesity is one of the most active and fast moving area in the basic biomedical research. Now, scientists had cloned the obese gene, clarified the structure of leptin, nailed down and cloned the gene of leptin receptor, partly revealed the mechanisms of leptin＇s effects which make the study of obesity entering the molecular age. It shows an attractive perspective for human being to cont rol the body weight and increase the health level. The recent progress of all these aspects is discussed in this review.