摘要
已有许多研究报道天然香豆素具有抗癌活性,它的抗癌机制与其具有的多项生理调节作用有关。本文从对细胞周期的影响、诱导细胞凋亡、SAPK/JNK/p38MAP等信号通路及对GSH转硫酶/NADPH醌氧化还原酶(GST/NQO)体系的影响等方面对天然香豆素的抗癌机制进行简要综述。
Many literatures on anti-cancer activities of natural occurring coumarins are available.The anti-cancer mechanisms of coumarins are related to the physiological modulations in the living body.This paper is aimed to review the anti-cancer mechanisms of coumarins from different aspects such as influences on cell cycles,induction of cell apoptosis,SAPK/JNK/p38MAP signaling pathways and the system of glutathione S-transferases （GST）/NADPH quinine oxidoreductase （NQO）.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第10期1174-1177,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
华侨大学校基金资助项目(06y0045)
关键词
香豆素
抗癌机制
细胞周期
凋亡
信号通路
coumarins
anti-cancer mechanism
cell cycles
apoptosis
signaling pathways
