c-erbB-2、ras、p53基因产物在大肠癌及癌前病变中的表达

The Expressions of c-erbB-2, ras and p53 Oncoproteins in Colorectal Carcinomas and Precancerous Lesions

目的：探讨c－erbB－2、ras、p53基因的表达与大肠癌发生发展的关系以及其对大肠癌早期诊断、预后判断的价值。方法：对45例大肠癌及36例癌旁非腺瘤型不典型增生、17例大肠腺瘤，用免疫组化方法检测基因产物的表达。结果：p53在大肠癌的阳性表达率为57．8％，p53蛋白高表达的癌旁非腺瘤型不典型增生及大肠腺瘤均为中度或高度不典型增生。p53蛋白表达与大肠癌的组织分化程度、淋巴结转移有关（P＜0．05）。p21、p185蛋白表达与大肠癌组织学分型、癌组织浸润程度、淋巴结转移无关，而与癌组织分化程度有关（P＜0．05）。结论：p53蛋白表达可能是大肠病变恶性倾向的一个独立标志。p53、p21、p185蛋白对大肠癌的发生、发展起重要作用。

To investigate the relationship of the exprsion of c - erbB - 2, ras, p53 gene proteins and deveopment in colorectal carcinoma and its clinical value in the early diagnosis and prognosis in colrectal carcinoma. Methods: With immunohistochemical assay 45 cases of colorectal carcinoma and 36 cases of non - adenomas dysplasia abjecent to colorectal carcinoma were studied, Results: p53 positive expression rate in colorectal careinoma is 57. 8%, non - adenomas dysplasia abjecent to colorectal carcinoma and colorectal adenoma which show high expression are both mederaely or highly dysplasia . The oveexpression of p53 relates with histologic grade and lymph node metastasis (P < 0 .05). No significant correlation exsited beween the expression of p53 and histologic type and dpgree of invasion. Conclusion : p53expression may be an independent marker of malignant potential. p53, p21 and p185 play important role inthe development of colorectal carcinomas .