急性缺氧对人体血液部分离子浓度的影响

Influence of acute hypoxia on concentrations of some serum ions in humans

目的通过正常及三种不同缺氧条件下血中Ｎａ＋、Ｃｌ－浓度及ｐＨ值的测定，探索急性缺氧对血电解质平衡的影响。方法１２名健康男性青年通过面罩吸入空气或含氧量为１４．５％、１１．２％、９．８％的氧氮混合气１５ｍｉｎ。采集静脉血，利用电解质分析仪对其中的离子浓度进行测定。结果与自身对照组相比，三种缺氧条件下的Ｎａ＋和Ｃｌ－浓度均显著降低（Ｐ＜０．０１）；ｐＨ值在１４．５％低氧期变化不明显（Ｐ＞０．０５），在１１．２％和９．８％低氧期显著降低（Ｐ＜０．０５）。结论血液中电解质浓度对缺氧变化非常敏感，由此可能引发机体的一系列变化，如酸碱平衡失调、钙平衡失调、血细胞损伤等。

Objective The purpose of this study is to explore the influence of acute hypoxia on blood electrolytes balance. Methods Twelve healthy young men served as subjects. Oxygennitrogen gas mixtures containing 21%、14.5%、11.2% and 9.8% oxygen were inhaled to simulate normal condition and three different levels of hypoxia for 15 minutes. Electrolyte analyzer was used to determine the concentrations of Na+、Cl- and pH of venous blood. Results Concentrations of Na+ and Cl- decreased significantly (P<0.01) after exposure to each level of hypoxia; pH value didn't change obviously after exposure to 14.5% hypoxia (P>0.05), but decreased significantly after exposure to 11.2% and 9.8% hypoxia (P<0.05) as compared with that of the control. Conclusion The concentrations of blood electrolytes is sensitive to hypoxia. Its' fluctuation may probably cause a series of changes in humans, such as acid and alkaline imbalance, calcium imbalance, and blood cell injury etc. They are of great importance to space medical examination and protection.