黄芪颗粒治疗原发性肾病综合征的疗效观察

The Clinical Effect Of Radix Astragali On Primary Nephritic Syndrome

目的:观察黄芪颗粒治疗原发性肾病综合征的疗效。方法:对39例病理改变为轻度系膜增生性肾小球肾炎的肾病综合征患者,随机分为2组,对照组(21例)用激素(泼尼松)+蒙诺治疗,实验组(18例)用激素(泼尼松)+血管紧张素转换酶抑制剂+黄芪颗粒治疗,观察各组治疗2w、4w、6w后24h尿蛋白、血浆白蛋白的变化。结果:实验组与对照组比较,治疗6w后,24h尿蛋白明显减少(p<0.05);治疗4w、6w后,血浆白蛋白明显提高(p<0.05)。结论:黄芪颗粒辅助激素治疗原发性肾病综合征能有效降低尿蛋白,增加血浆白蛋白水平。

Objective ：To observe the clinical effect of radix astragali on primary nephritic syndrome. Methods：39 cases diagnosed as primary nephrotic syndrome[pathology was mesangial proliferative glomerulonephritis ） were randomly divided into control group （21cases） and treatment group （ 18cases）. The control group was treated with prednisone and Angiotensin converting enzyme inhibitor. The treated group was treated with radix astragali in addition to prednisone and Angiotensin converting enzyme inhibitor. Proteinuria and serum albumin were measured after 2,4 ,6weeks. Results：Radix astragali combined with prednisone and Angiotensin converting enzyme inhibitor can obviously reduced proteinuria after 6 weeks in the treatment group, while plasma albumin increased significantly after 4 ,6 weeks compared to control group. Conclusion：Radix astragali combined with prednisone can obviously reduce proteinuria and significantly incresse plasma albumin.