110℃碘化油-顺铂混悬剂超选择肝动脉化疗栓塞治疗中晚期肝癌术后不良反应及对患者生存期的影响

The study of complications and existent term of 110℃DDP-lipiodol via Intra-arterial Thermochemotherapy in Terminal Hepatic Carcinoma

目的:观察110℃碘化油-顺铂混悬剂超选择肝动脉化疗栓塞治疗中晚期肝癌术后患者的临床不良反应的发生情况及该种治疗方法对患者生存期的影响。方法:跟踪随访对照组和实验组患者术后不良反应发生的情况及生存期的长短,进行回顾性对照分析。结果:实验组栓塞术后的发热、恶心、肝功能损害等不良反应程度较对照组略重,但差异无统计学意义,未发生特殊或严重的术后并发症及副反应。实验组的患者生存期较对照组延长,差异有统计学意义。结论:110℃碘化油-顺铂混悬剂超选择肝动脉化疗栓塞治疗中晚期肝癌能有效延长患者生存期,而无严重的不良反应及并发症,是一种利大于弊的有效治疗中晚期肝癌的介入治疗方法。

Objective ：To observe the acomplications and existent term of 110℃ DDP-lipiodol via intra-arterial thermochemotherapy in terminal hepatic carcinoma. Methods：sixty patients with advanced hepatic carcinoma were divided into study group and control group. Intra-hepatic-arterial chemoembolization was performed in all patients. For patients in study group the solution was warmed up to 110℃ ,while the patients in control group the temperature of solution was normal. Observation on the acomplications and existent term after the therapy was made. Results：The symptoms of study group, such as fever,queasiness,damage of hepatic function is slightly heavier than control group. But it is no statistical meaning. There are no difference in bad reaction and complication of the therapy. The eXistent term of study group is longer than control group. Conclusion：110℃ DDP-lipiodol via intra-aryerial thermochemotherapy is an effective and safe treatment for the patient with advanced hepatic carcinoma. The advanstages of the method is more than the disadvantages.