子宫内膜癌组织中的rasp21及GST-pi表达的对比

A STUDY OF EXPRESSION OF RASP21,GSTPI IN ENDOMETRIAL CARCINOMA

目的探讨ｒａｓｐ２１与ＧＳＴｐｉ在子宫内膜癌发生、发展过程中的表达状态及意义。方法用免疫组化ＬＳＡＢ法对３２例子宫内膜腺癌和１２例子宫内膜增生过长组织进行检测，观察ｒａｓｐ２１和ＧＳＴｐｉ在病变组织中的分布。结果３２例子宫内膜癌中ｒａｓｐ２１、ＧＳＴｐｉ阳性率分别为６５．６％（２１／３２）和７１．９％（２３／３２）；１２例子宫内膜增生过长组织中的ｒａｓｐ２１，ＧＳＴｐｉ阳性率分别为１６．７％（２／１２）和３３．３％（４／１２）。ｒａｓｐ２１，ＧＳＴｐｉ在癌组织中的表达均高于子宫内膜增生过长（Ｐ＜０．０１；Ｐ＜０．０５）。结论ｒａｓｐ２１和ＧＳＴｐｉ均与子宫内膜癌的发生发展有关，两种标记物在子宫内膜高、中分化癌及癌前病变中的表达有协同作用。

Objective To explore the relation between rasp21. glutathion stransferases(GSTpi) and endometrial carcinoma.Method Expression of rasp21, GSTpi were studied in 44 cases of endometrial malignant and benign lesions by LSAB immunohistochemical technique.Result The results showed that the positive rates of rasp21 and GSTpi expression were 65.6% and 71.8% respectively in endometrial carcinoma and 16.7%,33.3% respectively in endometrial hyperplasia. The expressions of rasp21, GSTpi in endometrial carcinoma were significantly higher than those in endometrial hyperplasia (P<0.01,P<0.025).Conclusion Rasp21 cooperates with GSTpi in the pathogenisis and development of endometrial carcinoma.The combined expression of rasp21 and GSTpi could be used as a consultative marker for the early diagnosis of endometrial carcinoma.