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早孕期人绒毛趋化因子CCL2及其受体CCR2的表达 被引量：3

Expression of Chemokine CCL2 and its Receptor CCR2 in Human First Trimester Placental Villi
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摘要 目的:分析人早孕绒毛组织趋化因子CCL2及其受体CCR2的转录和翻译表达。方法:收集人早孕期胎盘组织30例,分离出绒毛组织,采用半定量RT-PCR、免疫组织化学法分析正常人早孕绒毛组织CCL2/CCR2的表达。结果:人早孕绒毛滋养细胞中等水平转录和翻译CCL2及CCR2。结论:CCL2/CCR2表达于母-胎界面的胎儿面绒毛组织,可能参与滋养细胞功能调控。 Objective： To prove the expression of chemokine CCL2 and its receptor CCR2 in human first-trimester placental villi. Methods： The transcription and translation of chemokine CCL2 and its receptor CCR2 in the first-trimester placental villi were analyzed by semi-quantitative RT-PCR and immunohistochemistry, respectively. Results： CCR2 and its ligand CCL2 were expressed moderately in human first-trimester placental villi. Conclusion： CCR2 and CCL2 are co-expressed by human first-trimester villous tissue.
作者 马方 杜美蓉 李大金
机构地区 复旦大学上海医学院附属妇产科医院暨妇产科研究所 上海市曙光医院宝山分院妇产科 海南医学院附属医院妇产科
出处 《生殖与避孕》 CAS CSCD 北大核心 2009年第11期755-758,共4页 Reproduction and Contraception
关键词 绒毛 趋化因子 CCR2/CCL2 母-胎界面 villi trophoblasts chemokine CCL2 CCR2
分类号 R714.1 [医药卫生—妇产科学]
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参考文献9

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同被引文献18

  • 1金妍,林其德,汪希鹏,肖云山,吕彩君,丁传伟.原因不明复发性流产患者巨噬细胞表面TSP1、CD36、CD47的表达及其细胞因子的分泌[J].现代妇产科进展,2006,15(12):926-929. 被引量：4
  • 2林其德,汪希鹏.原因不明复发性流产的病因病理生理机制与治疗研究进展[J].中国实用妇科与产科杂志,2007,23(1):5-8. 被引量：65
  • 3米亚英,杨俊英.自然流产小鼠蜕膜组织肿瘤坏死因子-α和单核细胞趋化蛋白-1的表达[J].中国计划生育学杂志,2007,15(7):411-413. 被引量：5
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  • 9Yu XW,Yan CF,Jin H,et al.Tumor ncrosis factor receptor 1 expression and early spontaneous abortion[J].Int J Gynecol Obstet,2005,88(1):44-48.
  • 10Mor G,Abrahams VM.Potential role of macrophages as immunnoregulators of pregnancy[J].Reprod Biol Endocrinol,2003,1:119.

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生殖与避孕
2009年 第11期

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