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Th17细胞与自身免疫性疾病的关系 被引量：5

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摘要 根据细胞的功能，经典地将CD4＋T细胞分为Th1、Th2辅助细胞以及调节性T细胞3个亚群。Th1细胞通过分泌干扰素（IFN）-1、白细胞介素（IL）-12等细胞因子，在抗感染、抗肿瘤反应中发挥重要作用，而同时，Th1活性异常升高也是器官特异性自身免疫病发病的重要机制之一；Th2细胞则通过分泌IL-4、IL-5、IL-13等细胞因子促进机体的体液免疫应答，另一方面也参与了哮喘、系统性自身免疫病的发病过程；
作者 徐雪 吕玲
机构地区 复旦大学医学院附属华山医院风湿科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2009年第12期859-862,共4页 Chinese Journal of Rheumatology
关键词 CD4+T细胞 自身免疫性疾病 器官特异性自身免疫病 系统性自身免疫病 TH1细胞 TH2细胞 调节性T细胞 体液免疫应答
分类号 R686 [医药卫生—骨科学]
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参考文献26

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  • 2Park H, Li ZX, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nat Immunol, 2005, 6:1133-1141.
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同被引文献51

  • 1臧敬五.自身免疫性疾病研究的新进展——骨桥蛋白在类风湿性关节炎中的病理机制研究[J].中国科学院院刊,2005,20(3):208-210. 被引量：53
  • 2吴长有.Th17细胞:一种新的效应CD4^+T细胞亚群[J].细胞与分子免疫学杂志,2006,22(6):695-697. 被引量：36
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  • 5Park H, Li ZX, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 2005, 6: 1133-1141.
  • 65Seiderer J, Elben I, Diegelmann J, et ",tl. Role of the novel Thl7 cytokine IL-17F in inflammatory bowel disease (1BD):upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p. Hisl61Arg polymorphism in IBD. lnflamm Bowel Dis, 2008, 14: 437-445.
  • 7Montes M, Zhang X, Berthelot L, et al. Oligoclonal myelin- reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Thl7 cells. Clin Immunol, 2009, 130: 133-144.
  • 8Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. Altern Med Rev, 2009, 14: 141-153.
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  • 10Ung VY, Foshaug RR, MacFarlane SM, et al. Oraladministration of eurcumin emulsified in earboxymethyl cellulose has a potent anti-inflammato effect in the IL-10 gene-deficient mouse model of IBD. Dig Dis Sci, 2010, 55: 1272-1277.

引证文献5

二级引证文献11

中华风湿病学杂志
2009年 第12期

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