期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

味觉细胞受体及信号转导的研究进展 被引量：3

原文传递
导出
摘要 味觉的产生主要是味觉细胞通过相关受体分子与溶液中的物质相互作用后产生味觉信号，刺激相关神经中枢所引发。目前，对味觉的研究主要集中在味觉受体分子和信号转导方面，以下将对味觉细胞受体及信号转导的最近研究进展作简要综述。
作者 耿传营 陈志华 向青
机构地区 中日友好医院临床医学研究所生物化学分子生物学研究室
出处 《中华口腔医学杂志》 CAS CSCD 北大核心 2009年第12期770-772,共3页 Chinese Journal of Stomatology
关键词 味觉信号 信号转导 细胞受体 受体分子 相互作用 味觉细胞 神经中枢
分类号 R341 [医药卫生—基础医学]
  • 相关文献

参考文献36

  • 1杨秀文,刘洪臣.口腔味觉感知的脑功能测试技术研究进展[J].中华口腔医学杂志,2006,41(10):639-640. 被引量：9
  • 2梁军,刘洪臣.味觉与脑功能之间联系的研究现状[J].中华口腔医学杂志,2005,40(5):439-440. 被引量：1
  • 3Hoon MA, Adler E, Lindemeier J, et al. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell, 1999,96 (4) :541-551.
  • 4Maruyama Y, Pereira E, Margolskee RF, et al. Umami responses in mouse taste cells indicate more than one receptor. J Neurosci, 2006,26 ( 8 ) : 2227 -2234.
  • 5Yasuo T, Kusuhara Y, Yasumatsu K, et al. Multiple receptor systems for glutamate detection in the taste organ. Biol Pharm Bull, 2008,31 ( 10 ) : 1833-1837.
  • 6Narukawa M, Kitagawa-Iseki K, Oike H, et al. Characterization of umami receptor and coupling G protein in mouse taste cells. Neuroreport ,2008,19 (12) : 1169-1173.
  • 7Nelson G, Chandrashekar J, Hoon MA, et al. An amino-acid taste receptor. Nature,2002, 416 (6877) : 199-202.
  • 8Zhao GQ, Zhang Y, Hoan MA, et al. The receptors for mammalian sweet and umami taste. Cell, 2003,115 ( 3 ) :255-266.
  • 9Damak S, Rong M, Yasumatsu K, et al. Detection of sweet and umami taste in the absence of taste receptor T1 r3. Science,2003, 301 (5634) :850-853.
  • 10Li X, Li W, Wang H, et al. Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet, 2005,1 ( 1 ) :27-35.

二级参考文献36

  • 1Faurion A, Cerf B, Le Bihan D, et al. fMRI study of taste cortical areas in humans. Ann N Y Acad Sci, 1998,855:535-545.
  • 2Kobayakawa T, Ogawa H, Kaneda H, et al. Spatio-temporal analysis of cortical activity evoked by gustatory stimulation in humans. Chem Senses 1999,24:201-209.
  • 3O'Doherty J, Rolls ET, Francis S, et al. Representation of pleasant and aversive taste in the human brain. J Neurophysiol,2001,85:1315-1321.
  • 4Cerf-Ducastel B, Van de Moortde PF, MacLeod P,et al. Interaction of gustatory and lingual somatosensory perceptions at the cortical level in the human: a functional magnetic resonance imaging study. Chem Senses, 2001,26:371-383.
  • 5O'Doherty JP, Deichmann R, Critchley HD,et al. Neural responses during anticipation of a primary taste reward. Neuron, 2002,33:815-826.
  • 6Shikama Y, Kato T, Nagaoka U, et al. Localization of the gustatory pathway in the human midbrain. Neui'osci Lett, 1996 ,218: 198-200.
  • 7Lee BC, Hwang SH, Rison R, et al. Central pathway of taste:clinical and MRI study. Eur Neurol, 1998,39:200-203.
  • 8Uesaka Y, Nose H, Ida M, et al. The pathway of gustatory fibers of the human ascends ipsilaterally in the pons. Neurology, 1998,50:827-828.
  • 9Faurion A, Cerf B, Van De Moortele PF, et al. Human taste cortical areas studied with functional magnetic resonance imaging: evidence of functional lateralization related to handedness. Neurosci Lea,1999 ,277 : 189-192.
  • 10Barry MA, Gatenby JC, Zeiger JD, et al. Hemispheric dominance of cortical activity evoked by focal electrogustatory stimuli. Chem Senses, 2001,26:471-482.

共引文献8

同被引文献41

  • 1BEAR MF,CONNORS BW,PARADISO MA.Neamscience exploring the brain[M].2nd Edition.Baltimore:Lippincott Williams Wilkins Inc,2001:482-493.
  • 2OZDENER H,YEE KK,CAO J,et al.Characterization and long-term maintenance of rat taste cells in culture[J].Chem Senses,2006,31(3):279-290.
  • 3于世凤.口腔组织病理学[M].第4版.北京:人民卫生出版社,2004:43-45.
  • 4Amrein H, Bray S. Bitter-sweet solution in taste trans- duction[J]. Cell, 2003, 112 (3)I: 283-284.
  • 5Kim MR, Kusakabe Y, Miura H, et al. Regional expres- sion patterns of taste receptors and gastdttcin in the mouse tongue[J]. Biochem Biophys Res Commun, 2003, 312 (2) : 500-506.
  • 6Jiang P, Cui M, Zhao B, et al. Identification of the cy- clamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3[J]. J Biol Chem, 2005, 280(40):34296-34305.
  • 7DuBois GE. Unraveling the bi6chemistry of sweet and u- mami tastes[J]. Proc Natl Acad Sei U S A, 2004, 101 (39) : 13972-13973.
  • 8Nie Y, Vigues S, Hobbs JR, e al. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detec- tion of sweet stimuli[J]. Curr Biol, 2005, 15 (21): 1948- 1952.
  • 9Zhao GQ, Zhang Y, Hoon MA, et al. The receptors for mammalian sweet and mnami taster Jl. Cell, 2003, 115 (3) : 255-266,.
  • 10Kusakabe Y, Kim MR, Miura H, et al. Regional expres- sion patterns of Tlr family in the mouse tongue[J]. Chem Senses, 2005, 30(Suppl 1) : i23-i24.

引证文献3

二级引证文献9

中华口腔医学杂志
2009年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部