一组慢性淋巴增殖性疾病的实验室与临床特征

Clinical and Laboratory Features of a Group of Cases with Chronic Lymphoproliferative Disorders

目的：进一步认识慢性淋巴增殖性疾病（CLD）的临床及实验室特征。方法：从临床经过、形态学、免疫标记等方面分析该组病例、结果：B细胞慢性淋巴细胞白血病（B－CLL）除具有成熟小淋巴细胞特征外，CD5+和SmIg+是其特殊的表型形式；毛细胞白血病（HCL）以全血细胞减少和巨脾为特征，CD11C、CD25和超微结构对其诊断有极大帮助；本文尚对伴有绒毛淋巴细胞的脾淋巴瘤（SLVL）、T细胞幼稚淋巴细胞白血病（T－PLL）较为少见的疾病的诊断进行了讨论。结论：综合分析临床和生物特征将有助于CLD的诊断。

Objective: To further define the chronic lymphoproliferative disorders (CLD). Methods:Based on the clinical features,cell morphology and immunophenotype, twenty-three cases of CLD classified after FAB proposals (1989) were retrospectively analyzed. Results:B-CLL was characteristic of mature small lymphocytic cell,CD5+ and Smlg+. A low blood cell count and splenomegaly were usually seen in HCL. CD11c+,CD25+ and ultrastructural analysis were useful for the diagnosis. In addition,the diagnostic criteria,cell morphology and biological characteristics for SLVL and T-PLL were discussed. Conclusion: Comprehensive analysis about clinical and biological features would be very useful to diagnose the CLD.