复发AL多药耐药基因的检测与预后关系

The Correlation Between the Expression of Multidrug Resistant Gene and Prognosis in the Relapse Acute Leukmia

目的：探讨复发急性白血病多药耐药性（MDR）的产生与化疗疗效及生存期的关系。方法：通过对39例复发型急性白血病细胞膜上P－170糖蛋白含量的检测，运用PCR技术，判断MDR结果，观察结果与化疗疗效及生存期的关系。结果：MDR阴性组CR率、平均生存期均明显优于阳性组。结论：该项检测结果对临床合理制订化疗方案有较好的参考价值，为预后的判断提供了重要依据。

Objective: To explore the relationship between the expression of mutidrug resistant (MDR) gene and prognosis. Method: the method of polymerase chain reaction was used to examine the expression of MDR1 gene in 39 relapse acute Leukemia patients. The levels of P-170 membrane protein was also detected. Results:The CR rate of the negative group of MDR was significantly higher than those in the positive group of MDR,the mean survival time was significantly longer than those in the positive group of MDR. Concolusion: The result of that examination may play an important role in the arrangement of chemotherapic regime of MDR gene and the judgement of prognosis in AML.