摘要
目的:为寻找早期诊断中枢神经系统白血病(CNSL)及疗效监测的敏感指标,对32例急性白血病患者脑脊液(CSF)中sIL-2R水平变化进行了检测。方法:采用双抗体夹心酶联免疫吸附法。结果:9例发生CNSL的患者CSF中sIL-2R水平为79.43±23.32U/ml,显著高于正常对照(8.32±3.97U/ml);鞘注治疗后,sIL-2R明显下降至25.06±14.29U/ml,6例可疑为CNSL的患者,CSF中sIL-2R水平为44.28±12.4U/ml,治疗后下降至14.19±4.13U/ml。而未发生CNSL的患者,sIL-2R水平为13.11±4.03u/ml,与正常对照相比无统计学意义。结论:CSF中sIL-2R水平的变化随白血病细胞浸润中枢神经系统而发生明显升高,并随治疗好转而下降;持续保持较高水平者(>30μ/ml)可能对化疗相对不敏感,预后差。在可疑为CNSL时,sIL-2R有可能作为CNSL的一项早期诊断指标。
In order to look for a sensitive criteria of early diagnosis and supervision of therapeutic effect of central nervous system leukemia(CNSL). CSF levels of soluble interleukin-2 recepter(sIL-2R) were determined in 32 cases with acute leukemia by the method of ELISA. The results showed that CSF levels of sIL-2R elavated obviously in CNSL. The sIL-2R levels were significantly higher than those of normal controls (P < 0.01 ). The CSF levels of sIL-2R decreased to normal range after treatment in some patients. No significan comparod with mormal controls (P>0.05). But in others were still higher than normal. In combination with the clinical information that some patients were sensitive to chemotherapy,but not in others.Therefore,the elavation of sIL-2R can be a sensitive criteria in early diagnosis of CNSL. There was no obriously difference in sIL-2R levels between patients of ALL and ANLL.
出处
《临床血液学杂志》
CAS
1998年第5期211-213,共3页
Journal of Clinical Hematology
基金
陕西省卫生厅中青年科学基金
关键词
中枢神经系统
白血病
急性
SIL-2R
Soluble interleukin-2 recepter Acute leukemia Central nervons system