急性白血病脑脊液白细胞介素Ⅱ受体测定及临床意义

The Clinical Significance of Detecting sIL-2R of CSF in Acute Leukemia

目的：为寻找早期诊断中枢神经系统白血病（CNSL）及疗效监测的敏感指标，对32例急性白血病患者脑脊液（CSF）中sIL－2R水平变化进行了检测。方法：采用双抗体夹心酶联免疫吸附法。结果：9例发生CNSL的患者CSF中sIL－2R水平为79．43±23．32U／ml，显著高于正常对照（8．32±3．97U／ml）；鞘注治疗后，sIL－2R明显下降至25．06±14．29U／ml，6例可疑为CNSL的患者，CSF中sIL－2R水平为44．28±12．4U／ml，治疗后下降至14．19±4．13U／ml。而未发生CNSL的患者，sIL－2R水平为13．11±4．03u／ml，与正常对照相比无统计学意义。结论：CSF中sIL－2R水平的变化随白血病细胞浸润中枢神经系统而发生明显升高，并随治疗好转而下降；持续保持较高水平者（＞30μ／ml）可能对化疗相对不敏感，预后差。在可疑为CNSL时，sIL－2R有可能作为CNSL的一项早期诊断指标。

In order to look for a sensitive criteria of early diagnosis and supervision of therapeutic effect of central nervous system leukemia(CNSL). CSF levels of soluble interleukin-2 recepter(sIL-2R) were determined in 32 cases with acute leukemia by the method of ELISA. The results showed that CSF levels of sIL-2R elavated obviously in CNSL. The sIL-2R levels were significantly higher than those of normal controls (P < 0.01 ). The CSF levels of sIL-2R decreased to normal range after treatment in some patients. No significan comparod with mormal controls (P>0.05). But in others were still higher than normal. In combination with the clinical information that some patients were sensitive to chemotherapy,but not in others.Therefore,the elavation of sIL-2R can be a sensitive criteria in early diagnosis of CNSL. There was no obriously difference in sIL-2R levels between patients of ALL and ANLL.