Trefoil因子和癌症关系研究进展

The relationship between trefoil factor and human cancer

Trefoil因子(TFFs)是出现在血浆的一种分泌性蛋白,主要由胃肠道粘液细胞分泌。一旦胃肠道粘膜遭受损伤,TFFs会介导粘膜上皮向损伤区迁移,提高迁移上皮的活力,促进粘膜血管形成,使粘膜快速复原。但TFFs以上功能调节异常,则会导致细胞过度增生,并向癌细胞转化,抑制癌细胞凋亡和失巢凋亡,促进癌组织血管形成。本文就TFFs促进细胞增生、抑制细胞凋亡和失巢凋亡、促进癌细胞侵润和转移、促进癌组织血管形成方面来阐述TFFs与人癌症的关系。

Trefoil factors（TFFs） present in the serum are proteins secreted chiefly by mucus-secreting cells of the gastrointestinal tract. In response to gastrointestinal injury, they are rapidly upregulated and act as motogens to facilitate cell migration into the lesion, thus forming a protective harries in a process known as restitution. In addition, TFFs are promoters of cell proliferation, potent inhibitors of apoptosis, prevent anoikis （ cell death induced by anchorage independence ） and stimulate angiogenesis. It is likely that the deregulation of these functions contributes to TFFs-mediated oncogenesis. Recent compelling evidence has emerged from experimental and clinical studies to indicate a pivotal role of TFFs in oncogenic transformation, growth and metastatic extension of common human solid turnouts. This review summarized the current evidences about promoting cell proliferation, cell resistance to apoptosis and anoikis, promoting cell migration and invasion and stimulating tissue angiogenesis for the involvement of TFFs in human cancer.