FOLFOX4和XELOX方案治疗局部进展期胃癌的疗效与毒副作用比较

Therapeutic effects and side effects of FOLFOX4 and XELOX on patients with advanced gastric cancer

目的:观察FOLFOX4和XELOX新辅助化疗方案治疗局部进展期胃癌的疗效和毒副作用。方法:将68例初治确诊为局部进展期胃癌的患者,随机分为2组,每组各34例,分别采用XELOX和FOLFOX4行术前化疗方案2个疗程。结果:XELOX组总有效率为47.06%(16/34),FOLFOX4组总有效率为41.08%(14/34),2组差异无统计学意义。FOLFOX4组恶心、呕吐、白细胞减少和口腔黏膜炎发生率较高,而XELOX组手足综合征发生率较高。结论:XELOX方案作为胃癌新辅助化疗方案,疗效与FOLFOX4方案相似,但XELOX方案毒副作用较轻,化疗时间短,对机体损伤小,易于接受。

Objective：To investigate the therapeutic effect and side effects of FOLFOX4 and XELOX as neoadjuvant chemotherapy on locally advanced gastric cancer.Methods：Sixty-eight patients with locally advanced gastric cancer were randomly assigned into two groups with 34 patients in each group.XELOX and FOLFOX4 were used preoperatively for two courses.Results：The total effective rate in Group XELOX was 47.06%（16/34） ,it was 41.08%（14/34） in Group FOLFOX4.The incidence rates of nausea,vomiting,neutropenia and oral mucositis were higher in group FOLFOX4.The incidence rate of hand-foot syndrome was higher in group XELOX.Conclusion：The program XELOX as neoadjuvant chemotherapy in gastric cancer is similar to the program FOLFOX4 in the therapeutic effect.The program XELOX can be controlled and has less side effects,its chemotherapy time is shorter and its damage to the body is slight.And it can be easily accepted.