磁共振成像测量健康中老年人嗅球体积的特点

MRI features of olfactory bulb volume in healthy middle and old-aged persons

目的利用磁共振成像（MRI）技术测量健康中老年人嗅球体积在不同年龄、性别和侧别问的差异，为进一步研究嗅觉障碍提供解剖学基础。方法95例健康中老年受试者，分为50—69岁组和≥70岁2组。所有受试者接受颅脑及嗅球MRI检查，比较嗅球体积在不同年龄、性别和侧别之间的差异。结果（1）50～69岁组的左侧嗅球体积、嗅球总体积和全脑体积（x±s，以下同）分别为（39．9±8．7）mm3、（81．7±16．8）mm3、（1281．9±140．2）cm3，大于≥70岁组的（34．5±10．4）mm3、（72．1±19．3）mm3、（1165．8±165．3）cm3，差异有统计学意义（t值分别为2．649、2．449、3．516，P值均〈0．05），而右侧嗅球体积及嗅球／脑体积比的差异则无统计学意义（t值分别为1．904、0．616，P值均〉0．05）。②男性受试者的左侧嗅球体积、右侧嗅球体积、嗅球总体积、全脑体积以及嗅球／脑体积比大于女性受试者，差异有统计学意义（t值分别为4．461、3．630、4．399、3．800、2．400，P值均〈0．05）。③女性受试者、50～69岁受试者、1〉70岁受试者左侧嗅球体积小于右侧，差异有统计学意义（t值分别为2．732、2．117、3．516，P值均〈0．05），男性受试者左右侧嗅球体积差异无统计学意义（t=2．649，P=0．110）。所有受试者的左侧嗅球／脑体积比均小于右侧嗅球／脑体积比，差异有统计学意义（t=3．183，P=0．002）。结论①嗅球及颅脑MRI检查可用于嗅球体积研究；②嗅球体积随年龄增加而减小，但嗅球／脑体积比无变化；③男性嗅球体积大于女性嗅球体积；④左侧嗅球体积小于右侧嗅球体积。

Objective To investigate the differences of olfactory bulb OB ） volumes between younger and older, male and female, left-side and right-side in healthy middle and old-aged persons by MRI. Methods Ninety five healthy middle and old-aged volunteers （ male： female = 45：50 ） were divided into 2 groups, group one included persons aged from 50 to 69, group two included persons elder than 70. The left-side, right-side and both-side volumes of OB, the volumes of brain and the ratio of OB/brain were measured by MRI. Results （ 1 ） The left-side and both-side volumes of OB （x ± s）, the volumes of brain [ （39. 89 ±8.7）ram3, （81.70 ±16. 8） mm3 and （ 1281.86 ± 140. 2） cm3 ] in 50 -69 years old group were respectively larger than those in ≥70 years old group [ （ 34. 45 ± 10. 4 ） mm3, （ 72. 10 ± 19. 3 ） mm3 and （ 1165.77 ± 165. 3） cm3 ] , and the differences reached statistical significance （ t were respectively 2. 649, 2. 449, 3. 516, all P 〈0. 05）. There were no significant differences of right-side OB volumes and the ratio of OB/brain between 50-69 years old group and ≥70 years old group （t were respectively 1. 904, 0. 616, each P 〉0. 05）. （2） The male＇s OB volumes of left-side, right-side and both-side, the brain volumes and the ratio of OB/brain were respectively larger than females＇, and the differences reached statistical significance （ t were respectively 4. 461,3. 630, 4. 399, 3. 800, 2. 400, all P 〈 0. 05 ）. （ 3 ） The right-side OB volumes were larger than left-side＇s and significant differences were found in female group, 50 -60 years old group and ≥70 years old group （t were respectively 2. 732, 2. 117, 3. 516, all P 〈0. 05）. There were no significant differences of OB volumes between left-side and right-side in female （t = 2. 649 ,P = 0. 110）. The ratio of right-side OB/brain were larger than the ratio of left-side＇s and the differences reached statistical significance （ t = 3. 183, P = 0. 002）. Conclusions MRI could be used to measure the volume of OB. The older the people , the smaller the OB volumes. There was no influence of age on the ratio OB/brain. The OB volumes of right-side were larger than those of left-side. The OB volumes of male were larger than those of female.