3US Food and Drug Administration. Challenge and opportunity on the critical path to new medical products[ EB/OL]. [2004 -03 - 16]. http://www, fda. gov/oc/initiatives/critiealpath/whitepaper. html.
4LI WAN PO A. Drug evaluation,drug development and pharmacogenetics:celebrating 30 years of progress [J]. J Clin Pharm Ther, 2005,30(1 ) :1 -4.
5KUMAR N, HENDRIKS BS,JANES KA, et al. Applying computational modeling to drug discovery and development [ J ]. Drug Discov Today,2006,11( 17-18 ) :806 - 811.
6HOOD L. Systems biology:integrating technology, biology and computation [ J ]. Mech Ageing Dev,2003,124 ( 1 ) :9 - 16.
7MICHELSON S. The impact of systems biology and biosimulation on drug discovery and development [ J ]. Mol Biosyst, 2006,2 (6-7) :288 -291.
8HOOD L, HEATH JR, PHELPS ME, et al. Systems biology and new technologies enable predictive and preventative medicine[J]. Science,2004,306 ( 22 ) : 640 - 643.
9KUNKEL EJ,DEA M,EBENS A,et al. An integrative biology approach for analysis of drug action in models of human vascular inflammation[ J]. FASEB J,2004,18( 11 ) :1279 - 1281.
10KUNKEL EJ,PLAVEC I, NGUYEN D,et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based model[J]. Assay Drug Dev Technol,2004,2 ( 4 ) :431 - 441.
6BERGGREN R,MLLER M, MOSS R. Outlook for the next 5 years in drug innovation [ J ]. Nature Reviews Drug Discovery,2012,11:435-436.
7Pharmaceutical Research and Manufacturers of America. Nearly 900 Medicines and vaccines in testing offer Hope in the fight against cancer[R]. Medicines in Development for Cancer, 201 1.
