阿托伐他汀对急性脑梗死患者临床及血流变学的影响

Effect of Atorvastatin on Clinical and Blood Rheology in Patient With Acute Cerebral Infarction

目的观察阿托伐他汀对急性脑梗死患者临床及血流变学的影响。方法将人选的急性脑梗死患者120例随机分为治疗组和对照组各60例,对照组用常规治疗方法(复方丹参注射液、依达拉奉注射液和奥扎格雷钠注射液静脉滴注,口服肠溶阿司匹林片等);治疗组在常规治疗的基础上加阿托伐他汀钙口服。两组均连续治疗3个月。观察两组治疗前后临床疗效(神经功能缺损程度改变)及血流变学等指标的变化。结果治疗组总有效率明显高于对照组(p<0.05);治疗后治疗组TC、TG、LDL—c极显著低于对照组(P<0.01);治疗组全血低切黏度明显低于对照组(P<0.05)。结论阿托伐他汀能有效调整血脂代谢,改善神经缺损评分,促进脑细胞功能恢复,且安全性好。

Objective To observe the clinical effect of atorvastatin in the treatment of acute cerebral infarction and observe the clinical impact of blood rheology. Methods 120 cases of patients with acute cerebral infarction were randomly divided into 60 cases of treatment group and 60 cases of control group. The control group got conventional treatment （compound Danshen injection, Edaravone Ozagrel injection and intravenous drip injection Note, oral enteric - coated aspirin tablets, etc. ）. The pationts in treatment group were given atorv-astatin calcium based on the conventional treatment. Patients in the two groups were treated for 3 months. The clinical efficacy and blood rheology indicators were observed. Results The total effective rate of the treatment group was significantly higher than that of the control group （P 〈0.05）. TC, TG, LDL - C was significantly lower than those in the control group （P 〈0. O1 ）. The whole blood viscosity was significantly lower than that in the control group （P 〈 0.05）. Conclusion Atorvastatin can effectively adjust the lipid metabolism and improve the neurological deficit scores, and promote functional recovery of brain cells, and has good security.