乳酸菌S-层蛋白的多样性及其研究方法

Heterogeneity of Putative Surface Layer Proteins in Lactobacilli and Its Research Methods

乳酸菌是人体和许多动物肠道的正常菌群,在预防肠道感染、促进人体健康方面,具有不可或缺的作用。乳酸菌通过竞争性黏附来抑制致病菌的繁殖。研究表明,乳酸菌的黏附作用与细胞表层蛋白密切相关。表层蛋白又名S-层蛋白（surface layer protein,Slp）,是许多细菌及古生菌细胞壁表面所包被的生物活性大分子,在一些乳酸菌中也发现了S-层蛋白的存在。S-层蛋白的相对分子质量在40000～200000间,而在已发现的乳酸菌中,S-层蛋白相对分子质量在25000～70000间。作者讨论了乳酸菌中S-层蛋白的多样性及主要特性,对乳酸菌S-层蛋白的研究方法进行了初步探索。

Lactobacilli, an important intestinal microbiota in human and animals, plays dominant role on the maintaining of gastrointestinal tract （GIT） stability and the intestinal health. The cell surface layer protein （S-layers, slp） was considered to be exhibited important role on the competitively inhibit pathogens. In this manuscript, the distribution, characters and the study methods were reviewed and introduced.