山茱萸多糖的生理活性研究

Studies on Nourishing Effects of Cornel Polysaccharide on Liver and Kidney

以肾阴虚小鼠模型、CCl4急性肝损伤小鼠模型及小鼠免疫低下模型探讨山茱萸多糖补益肝肾的作用。以负重游泳时间、耐缺氧时间、血清超氧化岐化酶(SOD)活力和丙二醛(MDA)含量为指标,考察山茱萸多糖对肾阴虚小鼠模型的作用;以丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、SOD和MDA含量为指标,考察山茱萸多糖对CCl4急性肝损伤小鼠模型的作用;以小鼠血清溶血素水平,考察山茱萸多糖对机体特异性免疫功能的影响。研究结果表明:山茱萸多糖能显著增强肾阴虚小鼠的负重游泳时间、耐缺氧时间,提高血清中SOD活性,降低血清中MDA含量;降低肝损伤小鼠血清ALT、AST水平和肝脏组织中MDA含量,提高肝脏组织中SOD活性;提高免疫低下小鼠血清溶血素水平。山茱萸多糖能增强小鼠免疫功能、保护肝脏组织和改善肾阴虚症状,并以此实现补益肝肾的作用。

The target of this research was to investigate the tonic effects of Cornel polysaccharide on liver and kidney in mice through kidney-yin deficiency model, CCl4-induced acute liver injury model and low-immunity model, it was found that cornel polysaccharide significantly （ 1 ） increase the swimming time, hypoxia tolerance time, serum SOD activity; （2） decrease MDA level and the serum hemolysin level; （3） decrease ALT, AST in injured mice serum and MDA in injured liver tissue; （4）but increase SOD activity in injured liver tissue, those results strong suggested that Cornel polysaccharide significantly enhance the body-specific immune function, inhibit acute liver injure and improve the symptoms of kidney-yin deficiency significantly. Furthremore, the results proven that Cornel polysaccharide has the nourishing effect on the liver and kidney in mice.