支气管哮喘患者血管紧张素Ⅱ变化的初步研究

Changes of angiotensin Ⅱ in patients with bronchial asthma

采用放射免疫法测定了３８例支气管哮喘患者血管紧张素Ⅱ（ＰＡＴⅡ）的含量，并探讨的与血气分析及电解质变化的关系。结果提示：中、重度支气管哮喘急性发作期血浆ＰＡＴＯ显著高于正常对照组（Ｐ＜０．０１），重度＊支气管哮喘缓解期血浆ＰＡＴⅡ仍高于对照组（Ｐ＜０．０５）．支气管哮喘急性发作期血浆ＰＡＴⅡ增高与低氧血症、呼吸性＊酸中毒、呼吸性酸中毒并代谢性酸中毒、高血钾及低血氯有关，与低氧血症的程度无关。建议中、重度支气管哮喘适＊量加用血管紧张素转换酶抑制剂治疗。

The concentration. of angiotensin Ⅱ( PAT Ⅱ ) was detected by radioimmunoassay is 38 patients with bronchial asthma .* Its relation to changes. of blood gas analysis. and electrolytes was also investegated . The results showedthat during the acute phase of mod-* erateand severebronchial asthma. the level of serum PATⅡwas higherthanthatintheofcontrolgroup.( P<0.01) , Intheremis- sion phasein severe patients, there wasstilla significant difference between the levels ofPATⅡin the patients and the control group ( P <0.05) . The high levels of PATⅡ in the acute phaseof, bronchial asthma wereassociated with hypoxemia, respiratory acidosis.* metabolic acidosis , hyperkalemia and hypocchloremia , but it was not linked with the degree of hypoxemia . It is suggested that appropriate dose of angiotensin - invertase inhibitor may play an important role treatment of patients with moderate and severe bronchial asthma .*