利喜定对慢性心力衰竭患者血浆脑钠肽水平及心功能的影响

Effects of Lixiding on Cardiac Function and Serum Level of Brain Natriuretic Peptide in Patients with Chronic Heart Failure

目的探讨利喜定对慢性心力衰竭(CHF)患者血浆脑钠素(BNP)水平和心功能的影响。方法将42例CHF患者随机分为利喜定组(23例)和硝普钠(19例),2组其余抗心衰治疗相同,疗程5d。测定治疗前后心率、血压,左心室射血分数(LVEF),血浆BNP浓度的变化。结果疗程结束后,利喜定及硝普钠组与治疗前相比,心率下降,LVEF升高,血浆BNP浓度降低(P<0.05);与硝普钠组相比,利喜定组心率及血浆BNP浓度降低更明显,差异有统计学意义(P<0.05),但是LVEF两组间无差别,无统计学意义,利喜定组低血压等并发症明显低于硝普钠。结论利喜定和硝普钠都能改善CHF的心功能,且利喜定降低血浆BNP的疗效优于硝普钠,并且不良反应低于硝普钠。

Objective To investigate the effects of Lixiding on cardiac function and serum level of brain natriuretic peptide in patients with chronic heart failure（CHF）.Methods 42 patients with CHF were randomly divided into two groups：Lixiding group（23 patient s） and sodium nitroprusside group（19 patients）.all the patients were treated for 3～5 days besides conventional therapy.Heart rates,Plasma BNP,and left ventricular ejection fraction（LVEF）,side effects were evaluated before and therapy.Results Lixiding and sodium nitroprusside significantly increased the LVEF,decreased the heart rates and plasma BNP（P〈0.05）,what＇s more,Lixiding group had much lower Plasma BNP and side effects than sodium nitroprusside group after treatment（P〈0.05）.Conclusion Both Lixiding and sodium nitroprusside improve cardiac function in patient s with CHF,moreover,Lixiding decreases the plasma BNP more significantly than sodium nitroprusside.