支气管肺炎患儿治疗前后血清hs-CRP、IGF-Ⅱ和IL-6水平检测的临床意义

Clinical significance of determination of changes of serum hs-CRP,IGF-Ⅱ and IL-6 levels after treatment in children with bronchopneumonia.

目的探讨支气管肺炎患儿治疗前后血清超敏C-反应蛋白(hs-CRP)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)和白细胞介素6(IL-6)水平检测的临床意义。方法应用放射免疫分析法和免疫比浊法对34例支气管肺炎患儿进行了治疗前后血清hs-CRP、IGF-Ⅱ和IL-6水平检测,并与30例正常健康儿童作比较。结果在治疗前,支气管肺炎患儿血清hs-CRP、IGF-Ⅱ和IL-6水平均非常显著地高于正常人组(P<0.01),经治疗一周后与正常儿童组比较无显著性差异(P>0.05)。对支气管肺炎患儿血清hs-CRP水平、血清IGF-Ⅱ和IL-6水平进行了相关分析,结果呈明显正相关。结论检测支气管肺炎患儿血清中hs-CRP、IGF-Ⅱ和IL-6水平的变化对疾病的诊断、治疗和预后判断均有重要的临床价值。

Objective To explore clinical significance of changes of serum high - sensitivity C - rective protein（ hs - CRP）, insulin - like growth factor-Ⅱ （ IGF -Ⅱ ） and interleukin - 6 （ IL - 6） levels after treatment in children with bronehopneumonia. Methods Serum hs - CRP was detected with immunoturbidimetry and IGF-Ⅱ and IL - 6 were detected with radio immunoassay before and after treatment in 34 children with bronchopneumonia. The results were compared with the levels of hs - CRP, IGF-Ⅱ and IL - 6 in 30 healthy children. Results Before treatment, serum hs - CRP, IGF-Ⅱ, and IL -6 levels in patients were significantly higher than those in controls（ P 〈0. 01 ）. After one week treatment, las - CRP, IGF-Ⅱ and IL - 6 levels were not significantly differem from those in control （ P 〉 0.05 ）. To analysis bronchial pneumonia on serum levels of las - CRP, IGF-Ⅱ , IL - 6, the results showed significant positive correlation. Conclusion Determination of serum hs - CRP, IGF -Ⅱ and IL -6 levels in children with bronchopneumonia was important for diagnosis and outcome prediction.