摘要
目的探讨支气管肺炎患儿治疗前后血清超敏C-反应蛋白(hs-CRP)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)和白细胞介素6(IL-6)水平检测的临床意义。方法应用放射免疫分析法和免疫比浊法对34例支气管肺炎患儿进行了治疗前后血清hs-CRP、IGF-Ⅱ和IL-6水平检测,并与30例正常健康儿童作比较。结果在治疗前,支气管肺炎患儿血清hs-CRP、IGF-Ⅱ和IL-6水平均非常显著地高于正常人组(P<0.01),经治疗一周后与正常儿童组比较无显著性差异(P>0.05)。对支气管肺炎患儿血清hs-CRP水平、血清IGF-Ⅱ和IL-6水平进行了相关分析,结果呈明显正相关。结论检测支气管肺炎患儿血清中hs-CRP、IGF-Ⅱ和IL-6水平的变化对疾病的诊断、治疗和预后判断均有重要的临床价值。
Objective To explore clinical significance of changes of serum high - sensitivity C - rective protein( hs - CRP), insulin - like growth factor-Ⅱ ( IGF -Ⅱ ) and interleukin - 6 ( IL - 6) levels after treatment in children with bronehopneumonia. Methods Serum hs - CRP was detected with immunoturbidimetry and IGF-Ⅱ and IL - 6 were detected with radio immunoassay before and after treatment in 34 children with bronchopneumonia. The results were compared with the levels of hs - CRP, IGF-Ⅱ and IL - 6 in 30 healthy children. Results Before treatment, serum hs - CRP, IGF-Ⅱ, and IL -6 levels in patients were significantly higher than those in controls( P 〈0. 01 ). After one week treatment, las - CRP, IGF-Ⅱ and IL - 6 levels were not significantly differem from those in control ( P 〉 0.05 ). To analysis bronchial pneumonia on serum levels of las - CRP, IGF-Ⅱ , IL - 6, the results showed significant positive correlation. Conclusion Determination of serum hs - CRP, IGF -Ⅱ and IL -6 levels in children with bronchopneumonia was important for diagnosis and outcome prediction.
出处
《临床和实验医学杂志》
2009年第12期14-15,共2页
Journal of Clinical and Experimental Medicine